Endocrine Abstracts

Background: The recently discovered myokin Irisin, a peptide originated by a proteolytic cleavage of the transmembrane protein fibronectin type III domain containing 5 (FNDC5) whose expression is induced by exercise and/or by increasing peroxisome proliferator-activated receptor (PPAR)-γ co-activator 1α (PGC-1α), has been considered a prognostic factor in Chronic Ischemic Cardiomyopathy and Acute Heart Failure. Nevertheless, no data are available on Irisin level...

Background: In heart failure with reduced ejection fraction (HFrEF), catabolic mechanisms have a strong negative impact on morbidity and mortality. The relationship between anabolic hormonal deficit, thyroid function and heart failure with preserved ejection fraction (HFpEF) has still been poorly investigated. For this reason, we tried to define the prevalence of multi-hormonal deficiencies in HFpEF patients and the relationships between hormonal deficits and echocardiographic...